Fetal gene therapy

Fetal Gene Therapy

Fetal gene therapy of -thalassemia in a mouse model

Fetuses with homozygous -thalassemia usually die at the third trimester of pregnancy or soon after birth. Hence, the disease could potentially be a target for fetal gene therapy. We have previously established a mouse model of -thalassemia. These mice mimic the human -thalassemic conditions and can be used as preclinical models for fetal gene therapy. We tested a lentiviral vector containing th...

The current status and future direction of fetal gene therapy

Anna L David, Michael Themis, Simon N Waddington, Lisa Gregory, Suzanne MK Buckley, Megha Nivsarkar, Terry Cook, Donald Peebles, Charles H Rodeck, Charles Coutelle Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London WC1E 6HX Gene Therapy Research Group, Section of Cell and Molecular Biology, Division of Biomedical Sciences, Imperial College ...

ژن درمانی Gene Therapy

Advances in fetal therapy

Fetal medicine is a rapidly evolving speciality with improving imaging, prenatal diagnosis and evolving technology. Advances in fetal therapy have enabled us to prevent and treat conditions and improve outcome. Although the most common forms of fetal therapy used currently are preventative non-invasive methods, invasive fetal therapies, both pharmacological and surgical are rapidly evolving. As...